Plume Geometry Challenges Webinar

Spray pattern and plume geometry are spray characterization techniques used during the development of pressurized metered-dose inhalers and nasal sprays. Plume geometry is required to evaluate test and innovator products in the generic approval pathway. Because a single “snapshot” image is typically used, plume geometry is generally perceived as variable and subjective. Subjectivity also comes from the analyst’s selection of the frame processed, the spray angle origin and the placement of “arms” to indicate the outer limits of the plume. When transferring or using plume geometry methods across labs, it is important for methods to specify the spray angle origin and the spray angle arms placement. In this study about the repeatability of plume geometry measurements across commercially available pMDI products, Chris Gruenloh shares a method that reduces both inter-analyst and product variability.